Prof. Zhiyong Liao

College for Life and Environmental Science

Wenzhou University

Cha-Shan University Town

Wenzhou 325035

China

Tel: 86-577-86596015

Email: zyliao@wzu.edu.cn

Education and job experience

1994-1998:  Department of Chemistry, Jiangxi Normal University, China.  B.S

1998-2003:  College of Life Sciences, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences. Ph.D

2004-2005:  College of Life Sciences, Jiangxi Normal University.  Assistant professor

2005-2007:  National Institute of Health, National Institute of Cancer, USA,Postdoctor

2008-2013:  College of Life and Environmental Science, Wenzhou University,Associate professor

2014-present: College of Life and Environmental Science, Wenzhou University,Professor

2019-present: Director of Department of science and technology, Wenzhou University

Research interests:

- Mining and transformation of active ingredients of traditional Chinese herbal medicine;

- Effects of natural products on anti-tumor, anti-oxidation, anti-aging, anti-diabetes (especially prevention and treatment of diabetes tissue damage), and related functional mechanism;

Research projects:

[1] Excavation, transformation and anti-diabetic effects of flavonoids from Cirsium japonicum. Funded by National Natural Science Foundation of China

[2] Screening of the Sargassum fusiforme polysaccharide fractions with anti-aging effect and preliminary study on anti-aging mechanism. Funded by National Natural Science Foundation of China.

[3] Character evaluation of tartary buckwheat germplasm resources in East China ecological region, active ingredient excavation, forage development and promotion. National Key R&D Program Intergovernmental International Science and Technology Innovation Cooperation Key Project.

[4] The formation mechanism of antigen receptor diversity and its origin. Funded by the National Basic Research Program of China.

[5] Study on the excavation and antitumor activity of new birch alcohols. Funded by Natural Science Foundation of Zhejiang.

[6] Anti-tumor activity of novel Betulin compounds and the related functional mechanism. Funded by Natural Science Foundation of Zhejiang.

Selected Publications:

[1] Yulong Lan, Xiaoliang Qi, Erya Cai, Yajing Xiang, XinXin Ge, Hangbin Xu, Xiaojing Chen, Ying Li, Yizuo Shi, Zhiyong Liao, Jianliang Shen. A modified hyaluronic acid hydrogel with strong bacterial capture and killing capabilities for drug-resistant bacteria-infected diabetic wound healing. International Journal of Biological Macromolecules. 2024 (under review)

[2] Chen Zheng, Xuan Wu, Ming Liu, Yulong Lan, Qian Liu, Erya Cai, ZhiyongLiao, Jianliang Shen. Photothermal‐enhanced in situ supramolecular hydrogel promotes bacteria‐infected wound healing in diabetes. Smart Medicine 2024

[3] Xuenan Chen, Xinyu Ran, Xuebo Wei, Lifei Zhu, Shaodong Chen, Zhiyong Liao, Ke Xu, Weidong Xia. Bioactive glass 1393 promotes angiogenesis and accelerates wound healing through ROS/P53/MMP9 signaling pathway. Regenerative Therapy 2024, 26: 132-144.

[4]  Wenwen Cheng, Cifeng Cai, Yifan Xu1, Xueqi Xiao, Tiantian Shi, Yueling Liao, Xiaoyi Wang, Shasha Chen, Meiliang Zhou, Zhiyong Liao. The TRIM21-FOXD1-BCL-2 axis underlies hyperglycaemic cell death and diabetic tissue damage.Cell Death and Disease 2023, 14: 825

[5]  Cifeng Cai, Wenwen Cheng, Tiantian Shi, Yueling Liao, Meiliang Zhou, Zhiyong Liao. Rutin alleviates colon lesions and regulates gut microbiota in diabetic mice. Scientific Reports 2023, 13:4897.

[6] Wenting Wen, Liangliang Yang, Xin Wang, Hongyu Zhang, Fangfang Wu, KeXu, Shaodong Chen, Zhiyong Liao. Fucoidan promotes angiogenesis and accelerates wound healing through AKT/Nrf2/HIF-1αsignalling pathway.International Wound Journal 2023, 1-13.

[7] Xuebo Wei, Zhiyong Liao, Liangliang Yang, Fangfang Wu, Shaodong Chen, Chuxiao Shao, Xin Wang, Keshen Xiao, Jian Xiao, Ke Xu, Da Suna, Hongyu Zhang. Phosphorus magnesium fiber regulates macrophage polarization through TRPM7 to accelerate wound healing. Applied Materials Today 2023, 31:101758.

[8]  Wenwen Cheng, Yongping Hu, Meiliang Zhou, Ivan Kreft, Tamara Lah Turnˇsek, Mingyan Zu, Zhiyong Liao. Tartary Buckwheat Flavonoids Improve Colon Lesions and Modulate Gut Microbiota Composition in Diabetic Mice.Evidence-Based Complementary and Alternative Medicine 2022, doi:10.1155/2022/4524444.

[9] Siya Wu, Xu Zhang, Jian Liu, Jianxi Song, Ping Yu, Peichao Chen, Zhiyong Liao, Mingjiang Wu, Haibin Tong. Physicochemical characterization of Sargassum fusiforme fucoidan fractions and their antagonistic effect against P-selectin-mediated cell adhesion. Int J Biol Macromol 2019, 133:656-662.

[10] Dongsong Nie. Hui Li. Yu Liu. Zhiyong Liao. Role of Spata34 in cell proliferation and its expression pattern in postnatal development of rat testis. Molecular Biology Reports 2018, 45: 2697-2705.

[11] Jiming Li, Jingjing Zeng, Lianpin Wu, Luyuan Tao, Zhiyong Liao, Maoping Chu, Lei Li. Loss of P53 regresses cardiac remodeling induced by pressure overload partially through inhibiting HIF1α signaling in mice. Biochemical and Biophysical Research Communications 2018, 501: 394-399.

[12] Fanfhua Gong, Zhiyong Liao, Qiongzhen Chen. FGF1 improves functional recovery through inducing PRDX1 to reduce autophagy and ROS after spinal cord injury. Journal of Cellular and Molecular Medicine 2018, 22:2727-2738.

[13] Tong Haibing, Qi D, Guan X, Jiang G, Liao Zhiyong, Zhang Xu, Chen Peichao, Li Nan, Wu Mingjiang. c-Abl tyrosine kinase regulates neutrophil crawling behavior under fluid shear stress via Rac/PAK/LIMK/cofilin signaling axis. Journal of Cell and Biochemistry 2018, 119: 2806-2817.

[14] Chen Peichao, He Dan, Zhang Ya, Yang S, Chen L, Wang S, Zou Huixi, Liao Zhiyong, Zhang Xu, Wu Mingjiang. Sargassum fusiforme polysaccharides activate antioxidant defense by promoting Nrf2-dependent cytoprotection and ameliorate stress insult during aging. Food and Function 2016, 7:4576-4588.

[15] You Xiuling, Sheng Jianghong, Liu Liu, Nie Dongsong, Liao Zhiyong. Three ferritin subunit analogs in Chinese giant salamander (Andrias davidianus) and their response to microbial stimulation. Molecular Immunology 2015, 67: 642-651.

[16] Liao Zhiyong, Chen Xiaojun, Nie Dongsong, Wang Jiajia, Wu Mingjiang. A RING finger protein 114 (RNF114) homolog from Chinese sturgeon (Acipenser sinensis) possesses immune-regulation properties via modulating RIG-I signaling pathway-mediated interferon expression. Fish Shellfish Immunology 2014, 41: 507-516.  

[17] Liao Zhiyong, Wu Zhihua, Wu Mingjiang. Cirsium japonicum flavones enhance adipocyte differentiation and glucose uptake in 3T3-L1 cells. Biological & Pharmaceutical Bulletin 2012, 35: 855-860.

[18] Sudhanshu Shukla, Ken-ichi Fujita, Qi Xiao, Zhiyong Liao, Susan Gareld, Srinivasa M. Srinivasula. A shear stress responsive gene product PP1201 protects against Fas-mediated apoptosis by reducing Fas expression on the cell surface. Apoptosis 2011, 16: 162-173.

[19] Zhiyong Liao, Mingjiang Wu, Xiaoli Chen. Anti-diabetic effect of flavones from Cirsium japonicum DC in diabetic rats. Archives of Pharmacal Research 2010, 33: 353-362.